Mission & Objectives
The mission of this project is to develop and test a prototypical drug platform with the principal capacity to neutralize any given virus.
- Create discrete, size-adaptable nano-shells that can fully engulf and neutralize entire virus particles, with variants for spherical and filamentous viruses (WP1)
- Create a set of molecular building blocks that can polymerize into virus-neutralizing shells on the surface of viruses (WP2)
- Establish a generic molecular selection pipeline against purified virus-like particles, purified viruses and viruses in serum yielding chemically modified DNA and RNA aptamers (WP3)
- Test the neutralizing effectiveness against virus-like particles & lentivirus pseudo-type particles as models for a variety of aggressive viral pathogens, and HIV, hepatitis B and adeno viruses as models for real enveloped and non-enveloped viruses (WP4)