Publications
Beyond Dimerization: Harnessing Tetrameric Coiled-Coils for Nanostructure Assembly
Angew Chem Int Ed Engl. 2024 Dec 12:e202422075. doi: 10.1002/anie.202422075. Online ahead of print.ABSTRACTVersatile DNA and polypeptide-based structures have been designed based on complementary modules. However, polypeptides can also form higher oligomeric states....
Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and Presentation of Protein Domains
ACS Nano. 2024 Oct 22;18(42):28748-28763. doi: 10.1021/acsnano.4c07701. Epub 2024 Oct 11.ABSTRACTModular protein engineering is a powerful approach for fabricating high-molecular-weight assemblies and biomaterials with nanoscale precision. Herein, we address the...
Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants
NPJ Vaccines. 2024 Sep 9;9(1):164. doi: 10.1038/s41541-024-00950-9.ABSTRACTUpdates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 variants of concerns (VOCs). Here we describe three novel in-silico...
The art of designed coiled-coils for the regulation of mammalian cells
Cell Chem Biol. 2024 Aug 15;31(8):1460-1472. doi: 10.1016/j.chembiol.2024.06.001. Epub 2024 Jul 5.ABSTRACTSynthetic biology aims to engineer complex biological systems using modular elements, with coiled-coil (CC) dimer-forming modules are emerging as highly useful...
Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract
J Control Release. 2024 Jul;371:179-192. doi: 10.1016/j.jconrel.2024.05.041. Epub 2024 May 29.ABSTRACTThe delivery of vaccines plays a pivotal role in influencing the strength and longevity of the immune response and controlling reactogenicity. Mucosal immunization,...
A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein
Civit L, Moradzadeh N, Jonczyk A, Neckermann P, Asbach B, Peterhoff D, Wagner R, Famulok M, Mayer G, Kjems J, Valero J. Int J Mol Sci. 2024 Apr 24;25(9):4642. doi: 10.3390/ijms25094642. ABSTRACT The COVID-19 pandemic has underscored the critical need for the...
Hepatitis B Virus Neutralization with DNA Origami Nanoshells
Willner EM, Kolbe F, Momburg F, Protzer U, Dietz H. ACS Appl Mater Interfaces. 2024 May 22;16(20):25836-25842. doi: 10.1021/acsami.4c03700. Epub 2024 May 10. ABSTRACT We demonstrate the use of DNA origami to create virus-trapping nanoshells that efficiently neutralize...
SARS-CoV-2 Neutralization Capacity in Hemodialysis Patients with and without a Fifth Vaccination with the Updated Comirnaty Original/Omicron BA.4-5 Vaccine
Liao BH, Platen L, Grommes M, Cheng CC, Holzmann-Littig C, Christa C, Haller B, Kappler V, Bester R, Werz ML, Platen E, Eggerer P, Tréguer L, Küchle C, Schmaderer C, Heemann U, Renders L, Protzer U, Braunisch MC.
Preorganized cyclic modules facilitate the self-assembly of protein nanostructures
Snoj J, Lapenta F, Jerala R.
A multiplexed bacterial two-hybrid for rapid characterization of protein-protein interactions and iterative protein design
Boldridge WC, Ljubetič A, Kim H, Lubock N, Szilágyi D, Lee J, Brodnik A, Jerala R, Kosuri S.
VIROFIGHT has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 899619.